Dedifferentiation of somatic cells to a pluripotent state intechopen. Stimulustriggered fate conversion of somatic cells into pluripotency, nature on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Authors yoshiki sasai pdf 9kb the webpage will open in a new tab. Haruko obokata, teruhiko wakayama, yoshiki sasai, koji kojima, martin p. One of two papers describing a reprogramming phenomenon called stimulustriggered acquisition of pluripotency stap in stap, lineagecommitted adult somatic cells are reprogrammed to.
The use of human genome editing to make edits in somatic cells for purposes of. Obokata h 1, wakayama t 2, sasai y 3, kojima k 4, vacanti mp 5, niwa h 6, yamato m 7, vacanti ca 4. Stimulustriggered acquisition of pluripotency also known as stap was a proposed method of. Here we report a unique cellular reprogramming phenomenon.
Direct reprogramming of somatic cells into induced neurons duration. Vacanti1 here we report a unique cellular reprogramming phenomenon, called stimulustriggered acquisition of pluripotency. The certification of the concentration of somatic cells somatic cell count, scc in cows milk. Stimulustriggered fate conversion of somatic cells i. Through realtime imaging of stap cells derived from purified lymphocytes, as well as gene rearrangement analysis, we found that committed somatic cells give rise to stap cells by. Stimulustriggered fate conversion of somatic cells into pluripotency in chronic wounds in human beings. Essential technical tips for stap cell conversion culture from. The certification of the concentration of somatic cells somatic cell.
Stimulustriggered acquisition of pluripotency wikipedia. Stimulus triggered fate conversion of somatic cells into. Stimulustriggered fate conversion of somatic cells into. Stimulustriggered fate conversion of somatic cells into pluripotency haruko obokata1,2,3, teruhiko wakayama3, yoshiki sasai4, koji kojima1, martinp. In stap, strong external stimuli such as a transient lowph stressor reprogrammed mammalian somatic cells, resulting in the generation of pluripotent cells. Pdf stimulustriggered fate conversion of somatic cells. Stimulustriggered fate conversion of somatic cells into pluripotency. Stimulustriggered acquisition of pluripotency \stap is a cellular. It was not clear why ordinary cells do not convert into stem cells when. The human body originates from a totipotent stem cell, the zygote. Stimulustriggered fate conversion of somatic cells into pluripotency article pdf available in nature 5057485.
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